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Original Article

Ann Hamd Uni. 2010; 1(1): 12-15

Reproductive risk factors and breast carcinoma: Does the association vary in our patients?

Maria Shabbir Saria, Masoom Raza Mirza.

Objective: This aim of this study was to determine the significance of various reproductive factors amongst Pakistani women suffering from breast carcinoma.
Materials and Methods: This observational study was carried out from March 2007 to February 2010 at Hamdard University hospitals and other private hospitals where authors worked. A total of 105 patients with histopathological diagnosis of carcinoma of breast were included in this study. On a pre-designed Proforma detailed history and various reproductive risk factors were recorded. According to menstrual status, these patients were divided in two groups. In group A patients were in their premenopausal age and in group B post menopausal age.
Results: Among these 105 patients, 48 were in group A and 57 in group B. Maximum number of cases 55% were seen above 50 years of age, another significant number of cases, 28.5% seen in between 30 to 40 years of age whereas 14.2% presented between 41-50 years. The mean age at menarche was 13.28 years in group A and 12.42 years in group B. Nulliparity was seen in 12.5% cases in group A and 5.26% in group B. History of first full term pregnancy (FFTP) below the age of 20 was present in majority of cases in both groups.
Conclusion: The results of this study show that most of the known reproductive risk factors like early menarche, late menopause and nulliparity associated with breast cancer do not seem to hold true in the Pakistani women. It is time we should start to work on other factors like environmental and genetic mutations in our population.

Key words: Breast, Carcinoma, Cancer, Risk, Genetics

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