Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research



Anti inflammatory property of salbutamol on acute and chronic models of inflammation

Asha D Jadhav, Sudhir L Padwal, Rakesh R Jadhav, Swapnil S Jadhav, Harshal N Pise, Mangal K Choure.

Abstract
Background: β2-Adrenergic receptor agonist agents were able to suppress the immune response by inhibiting release of IL-12 and production of TNF-α by the direct stimulation of β-adrenergic receptors on inflammatory immune cells. In addition to bronchodilator action, salbutamol could exert anti-inflammatory action.

Aims and Objective: To find the anti-inflammatory effect of salbutamol in acute and chronic models of inflammation.

Materials and Methods: Wistar albino rats of either sex weighing 200250 g were used. Anti-inflammatory activity of salbutamol (2 mg/kg) was evaluated and compared with aspirin (300 mg/kg) using acute carrageenan method and formalin-induced arthritis method of inflammation. The result was statistically analyzed by one -way analysis of variance followed by Bonferroni test.

Results: The tested drug salbutamol at a dose of 2 mg/kg was found to possess significant anti-inflammatory activity in both acute and chronic methods of inflammation as compared to control but lesser than that of aspirin in carrageenaninduced paw edema and comparable with that of standard drug aspirin at a dose 300 mg/kg in formalin-induced arthritis.

Conclusion: Salbutamol possesses anti-inflammatory activity in acute and chronic methods of inflammation. Stimulation of β2-adrenergic receptors may have a predominant role in modulation of anti-inflammatory activity.

Key words: Salbutamol; Inflammation; Carageenin



Similar Articles

Research advances on how metformin improves memory impairment in "chemobrain".
Alhowail A, Chigurupati S
Neural regeneration research. 2022; 17(1): 15-19

Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation.
Li J, Kumari T, Barazia A, Jha V, Jeong SY, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer MC, Cho J
The Journal of experimental medicine. 2022; 219(1):

HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models.
Lun P, Ji T, Wan DH, Liu X, Chen XD, Yu S, Sun P
Neural regeneration research. 2022; 17(4): 887-897

Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration.
Rickman AD, Hilyard A, Heckmann BL
Neural regeneration research. 2022; 17(2): 246-250

Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis.
Wei QQ, Hou YB, Zhang LY, Ou RW, Cao B, Chen YP, Shang HF
Neural regeneration research. 2022; 17(4): 875-880


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites