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Molsidomine (MOL) reducespostoperative pelvic adhesion: A rat uterine horn model

Isil Koleli, Hakan Parlakpinar, Onural Ozhan, Kevser Tanbek, Nurhan Sahin, Ercan Yilmaz, Bahar Sariibrahim, Lale Bakir.




Abstract
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Aim: Postoperative pelvic adhesions (PPAs) are a common complication that leads to many problems. This study aimed to compare the role of Seprafilm (a protective barrier), and molsidomine (MOL), recognized for its antioxidative and antiproliferative effects, in preventing pelvic adhesion.
Material and Methods: A total of 30 of female Wistar albino rats were randomly divided into 3 groups. They underwent bilateral uterine horn injury. The rats in the Sham group (n=10) received no special treatment. The rats in the Seprafilm group (n=10) were treated withSeprafilm. The rats in the MOL group (n=10) received 10 mg/kg MOL orally for 14 days. Adhesion scores were evaluated using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively.
Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)] and Seprafilm [4 (1-5)] (p

Key words: Seprafilm; Hyaluronic Acid; Molsidomine; Pelvic Adhesions.






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