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Original Research

RMJ. 2014; 39(4): 425-427

Prostate specific antigen (PSA) as a predictor of biological behavior of prostate cancer

Durre Shohab, Mohammad Athar Khawaja, Mohammad Imran Jamil, Asad Ur Rehman, Saeed Akhter.

Objective: We evaluated PSA as a predictor of biological behavior of prostate cancer by comparing it with Gleason score.
Methodology: We retrospectively studied 105 prostate cancer patients with mean age of 69.61years (range=53-90). Seventy-four patients had Gleason score of ≤7 (70.5%) while 31 had Gleason of >7 (29.5%). Fifty patients had PSA between0.1-20 ng/ml (47.6%), 25 had between 20.1-50ng/ml (23.8%) while 30 had >50ng/ml (28.6%).
Results: Median PSA in patients with Gleason ≤7 group was 18.46ng/ml compared to 61.60ng/ml in Gleason >7group. 54% patient in Gleason ≤7 group had PSA between 0.1-20, 28.4% had between 20.1-50, 17.6% had >50 compared to 32.3%, 12.9% and 54.8%, respectively in Gleason >7 group.
Conclusion: High PSA is directly associated with high Gleason score and can be used to predict the presence of high grade prostate cancer.

Key words: Prostate specific antigen (PSA), prostate cancer, Gleason score.

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