Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

Effect of Trema guineensis (celtidaceae) on ethanol-induced hypertension in Wistar rats.

Balakiyém KADISSOLI, Aklesso Piwèlong MOUZOU, Tcha PAKOUSSI, Kwashie EKLU-GADEGBEKU, Kodjo A. AKLIKOKOU, Messanvi GBEASSOR.

Objective: Trema guineensis is a traditional medicinal plant used to treat cardiovascular diseases in Africa. Here, we evaluated the effects of its hydro-alcoholic leaves on ethanol-induced hypertension.
Method: Four groups of five rats each were used in this study. Group I, the control group, received distilled water (10 mL kg-1), Group II received ethanol (35°) at 3 g/kg, and Groups III and IV received ethanol (35°) at 3 g/kg followed by 200 and 400 mg/kg extract respectively. Ethanol solutions were administered over eight weeks.
Results: The ethanol solutions increased body weight, blood pressure, superoxide dismutase (SOD), and malondialdehyde (MDA), and reduced glutathione (GSH) and nitric oxide (NO). As for the hematological parameters, the ethanol solutions reduced hemoglobin (HB), red blood cells (RBCs), white blood cells (WBCs), platelets (PLTs), polymorphonuclear cells (PNs), and lymphocytes (LYs), as well as corpuscular volume (VGM) compared to the control group. The T. guineensis extract significantly prevented increased body weight, blood pressure, SOD, MDA, GSH, and NO. The extract also normalized hematological parameters.
Conclusion: These results suggest that this extract contains antihypertensive properties that protect against against ethanol-induced hypertension.

Key words: hypertension; Trema guineensis; antioxidant; oxidative stress; ethanol; hematological parameters.

Full-text options

Full-text Article

American Journal of Diagnostic Imaging


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.