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Review Article

SRP. 2020; 11(11): 315-318


Design and Synthesis of Possible Mutual Prodrugs of (Nsaid) Etodolac and Tolmetin with (Cytotoxic) Gemcitabine

Ammar Abdul Aziz Alibeg, Abbas H. Abdulsada, Noor H. Nasser, Karrar Abdil Aziz Ali beg.

Abstract
[NSAIDs] Non-steroidal anti-inflammatory drugs consider an important group of drugs due to their properties as anti-inflammatory and it have both antipyretic and pain killer activities. [COX-II] plays an important role all over oncogenesis and here we attempt the same thing to search the use of [NSAID] (Etodolac & tolmetin) in conjugation with current cytotoxic agent (Gemcitabine) for the prevention and/or management of cancer. This study distinguishes the designing and synthesis of mutual prodrug of [NSAID] & gemcitabine, which is specified to create the concomitantly pharmacological action as a one chemical entity with amend of targeting of drug. The synthesized compound was conferred by TLC, CHNS, FTIR and physicochemical properties. The newly synthesized prodrug is predicted to reduce the adverse effects of [NSAIDs] on the (GIT) gastrointestinal tract with enhancement of gemcitabine oral bioavailability and its targeting.

Key words: Etodolac, tolmetin, gemcitabine, drug targeting, mutual prodrug.






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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.