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Evaluation of one-shot vincristine sulfate combined with surgical excision as a new regimen for treatment of canine transmissible venereal tumorKhaled Abouelnasr, Mohamed A. Hamed, Rasha Eltaysh, Eman Abo Elfadl, Shefaa Bazeed, Samah Ibrahim, Liana Fericean, Foad Farrag, Mohamed Salem, Awad Rizk. Abstract | | | | Objective: The purpose of this study was to investigate the effectiveness of surgical excision combined with a single shot of vincristine sulfate for treating transmissible venereal tumor (TVT) in dogs.
Materials and Methods: Fifty-two dogs were divided randomly into two groups (n = 26). Dogs in Group I were treated surgically by debulking the tumorous mass, whereas dogs in Group II were subjected to a combination of surgery and a single injection of vincristine sulfate.
Results: Female dogs showed a high prevalence of TVT compared to males (67.3%, n = 35 vs. 32.7%, n = 17), respectively. The German shepherd’s breed showed a high prevalence of TVT compared to other breeds. There was a positive association between sex and outcomes. Most occurrences of regret in Group II were reported in females (n = 16, 61.5%) compared to male dogs (n = 10, 38.5%). There was also a positive association between breed and outcome. Most occurrences of regret in Group II were reported in German shepherd dogs (n = 16) compared to Group I (n = 7). In Group I, 15 dogs (57.7%) showed a complete regression, and 11 (42.3%) underwent recurrence. However, in Group II, 21 dogs (80.7%) showed a complete regression, and 5 dogs (19.2 %) underwent recurrence.
Conclusions: It appears therefore that the simultaneous use of surgery and administration of a single dose of vincristine sulfate could be considered a combination therapy for TVT as it reduces the risk of recurrence and has a reasonable cost. Recognizing potential risk factors associated with TVT in dogs may be helpful in constructing the best preventive measures.
Key words: Transmissible venereal tumors; surgical excision; dogs; vincristines ulphate
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