ADVERTISEMENT

Home|Journals|Articles by Year|Audio Abstracts
 

Original Article



Evaluation of one-shot vincristine sulfate combined with surgical excision as a new regimen for treatment of canine transmissible venereal tumor

Khaled Abouelnasr, Mohamed A. Hamed, Rasha Eltaysh, Eman Abo Elfadl, Shefaa Bazeed, Samah Ibrahim, Liana Fericean, Foad Farrag, Mohamed Salem, Awad Rizk.




Abstract

Objective: The purpose of this study was to investigate the effectiveness of surgical excision combined with a single shot of vincristine sulfate for treating transmissible venereal tumor (TVT) in dogs.
Materials and Methods: Fifty-two dogs were divided randomly into two groups (n = 26). Dogs in Group I were treated surgically by debulking the tumorous mass, whereas dogs in Group II were subjected to a combination of surgery and a single injection of vincristine sulfate.
Results: Female dogs showed a high prevalence of TVT compared to males (67.3%, n = 35 vs. 32.7%, n = 17), respectively. The German shepherd’s breed showed a high prevalence of TVT compared to other breeds. There was a positive association between sex and outcomes. Most occurrences of regret in Group II were reported in females (n = 16, 61.5%) compared to male dogs (n = 10, 38.5%). There was also a positive association between breed and outcome. Most occurrences of regret in Group II were reported in German shepherd dogs (n = 16) compared to Group I (n = 7). In Group I, 15 dogs (57.7%) showed a complete regression, and 11 (42.3%) underwent recurrence. However, in Group II, 21 dogs (80.7%) showed a complete regression, and 5 dogs (19.2 %) underwent recurrence.
Conclusions: It appears therefore that the simultaneous use of surgery and administration of a single dose of vincristine sulfate could be considered a combination therapy for TVT as it reduces the risk of recurrence and has a reasonable cost. Recognizing potential risk factors associated with TVT in dogs may be helpful in constructing the best preventive measures.

Key words: Transmissible venereal tumors; surgical excision; dogs; vincristines ulphate






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Author Tools
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.