Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis

Adil Ugur Cetin, Fatih Kamis, Ece Unal Cetin, Mehmet Arslan, Yavuz Beyazit.




Abstract

Acute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself. Although a variety of factors reported to have an association with disease severity, the role of Tenascin-C and procalcitonin in the pathophsiology of the disease has not been clearly elucidated yet. Therefore, this study aimed to assess whether tenascin-C and procalcitonin would be useful in predicting disease severity and prolonged hospital stay in conjunction with several prognostic scoring systems. A total of 44 AP patients (male/female: 24/20), and 40 healthy subjects (male/female: 20/20) were enrolled in this study. Tenascin-C and procalcitonin levels with other markers of inflammation were measured for all study participants. Prognostic scoring systems were used as to predict the disease severity in AP patients. Serum tenascin-C levels was higher in AP patients at onset of the disease compared with healthy controls. There were statistically significant and positive differences identified between serum Tenascin-C with Atlanta (p=0.000 r=0.538), Ranson (p=0.041 r=0.310) and Imrie (p=0.039 r=0.312) scoring systems. There was a statistically significant and positive correlation between CRP with serum tenascin-C (p=0.015 r=0,366) levels. Serum tenascin-C levels had high sensitivity (76.5%) and specificity (77.8%) for prediction of severe pancreatitis according to the Atlanta scoring system (AUC:0.809). The present study demonstrated that tenascin-C and procalcition levels are elevated in AP. Moreover, the appraisal of tenascin-C levels in patients with AP in conjunction with other markers of inflammation may provide additional information in estimating AP severity.

Key words: Acute Pancreatitis, tenascin-c, procalcitonin, prognostic markers






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.