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Camellia sinensis and epicatechin abate doxorubicin-induced hepatotoxicity in male Wistar rats via their modulatory effects on oxidative stress, inflammation and apoptosis

Osama M. Ahmed, Manal M. Abdul-Hamid, Ahlam M. El-Bakry, Hanaa M. Mohamed, Fatma El-zahraa S. Abdel Rahman.

Cited by 15 Articles

This study aimed to assess the preventive effects of Camellia sinensis (green tea) leaf aqueous extract and epicatechin and to scrutinize their possible mechanisms of action in doxorubicin-induced liver injury. Phytochemical screening of Camellia sinensis aqueous extract was performed by LC/ESI-MS/MS that revealed the presence of epicatechin and other polyphenols. Male Wistar rats were intraperitoneally injected with doxorubicin (4 mg/kg/week) and were orally treated with Camellia sinensis aqueous extract (200 mg/kg) or epicatechin (25 mg/kg) every other day for 6 weeks. The treatments of doxorubicin-injected rats with the extract and epicatechin resulted in a marked amelioration of the deteriorated effects on albumin, AFP and total bilirubin levels as well as ALT, AST, ALP and GGT activities. The treatments also alleviated the altered serum TNF-α and IL-4, liver LPO and GSH levels as well as liver SOD, GPx and GST activities. In association, the expression of liver NF-κB, COX-2, p53 and caspase-3 was remarkably decreased, the expression of Bcl-2 was significantly increased, and the liver histological architecture were remarkably amended by treatments. Camellia sinensis aqueous extract and epicatechin may have effective chemopreventive potentials against doxorubicin-induced hepatotoxicity via reinforcement of antioxidant defense system and attenuation of the inflammatory and apoptotic effects.

Key words: Camellia sinensis; epicatechin; doxorubicin; hepatotoxicity; rats

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