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Trypanosoma evansi causes thyroxin imbalance with biochemical alterations in wistar rats

Sirigireddy Sivajothi, V. C. Rayulu, Bhavanam Sudhakara Reddy, Karumuri Nalini Kumari.

Animals affected with Trypanosoma evansi show rare serum hormonal disturbances. One of the important hormones for livestock is thyroxin, and the level of thyroxin may be reduced during the T. evansi infection. The objective of the study was to investigate thyroxin level during experimentally induced T. evansi infection in Wister albino rats. Wistar albino white rats (n=12) were challenged with the local strain of T. evansi (at 5x105 trypanosomes/animal subcutaneously). At the high parasitemia, blood was collected from the rats, and serum was separated, which was subjected for biochemical evaluation. Decreased total serum thyroxin (2.91 0.04 g/dL) and free thyroxin (1.30 0.05 ng/dL) levels (p

Key words: Anemia, Biochemical alterations, India, Rats, Trypanosoma evansi, Thyroxin

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