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Original Research

Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe.


Aim: The present research work was carried out to isolate and identify the chemical constituent responsible for the antinflammatory activity of Russelia equisetiformis.
Method: Isolation was carried out using column chromatography. The structure of the isolated compound was identified and established using the available spectroscopic techniques including high-resolution electron mass spectrum. The anti-inflammatory activity was evaluated using egg albumin-induced paw edema, formaldehyde–induced arthritis and cotton pellet granuloma in-vivo tests. Prednisolone was used as a standard drug.
Results: Lupeol was isolated as colorless crystals (mp 213-215OC).Lupeol at the doses of 10, 20, 40 mg/kg produced significant (P

Key words: Russelia equisetiformis, Scrophulariacae, lupeol isolation, Anti-inflammatory activity

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