Abstract

It has been established that drugs can induce esophageal mucosal injury. Doxycycline induced esophageal injury has contributed to most of drug induced esophageal injuries. In this study, two cases are presented. Two females who are 27 and 30 year sold, applied to our hospital witht he complains of an acute onset odynophagia, dysphagia and retrosternal pain after using doxycycline for their genital system infection. Endoscopic examination detected semicircular deep ulceration at the middle esophagus. Their symptoms improved after 3 days of initiation of pantoprazole and liquid sucralfate following discontinuation of doxycycline. Drug induced esophageal injury is a common condition. Use of drug should be investigated in patients presenting with similar symptoms.

Key words: Doxycycline, esophagus injury,dysphagia