Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Expression of p53 and Ki-67 in oral dysplasia and Squamous cell carcinoma: An immunohistochemical study

Sharmistha M Patel, Kinjal A Patel, Prashant R Patel, Bhavna Gamit, Rasik N Hathila, Swati Gupta.




Abstract

Background: Oral cancers are a major health problem in developing country. They usually progress from premalignant conditions of oral cavity. Early diagnosis of these premalignant lesions by histopathology with help of immunohistochemistry can prevent morbidity and many other complications.

Aims & Objectives: To investigate the expression of p53 protein and Ki67 antigen in normal, oral premalignant and oral malignant lesions and to find correlation of the expression of this antigen in various premalignant and malignant oral lesions.

Materials and Methods: This study comprises of 39 cases of oral lesions (premalignant and malignant). After processing of representative tissue block, H&E and IHC stain with Ki-67 and p53 immunomarkers were carried out.

Results: Total 39 cases of premalignant and malignant oral lesions were reported in our study. Strong association was found in expression of both p53 and Ki-67 immunomarkers in premalignant and malignant oral lesions in compared to normal mucosa in our study.

Conclusion: Increased expression of p53 and Ki-67 immunostain was significantly correlated with progression of oral epithelium from normal to neoplasia and increased expression of these antigens suggest that they may be useful indicator of malignant transformation in dysplastic lesions

Key words: Oral Squamous Cell Carcinoma; Oral Dysplasia; Immunohistochemistry (IHC); p53; Ki-67






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.