Estimated Glomerular Filtration Rate (eGFR) Values as Predictor of Renal Insufficiency in Advanced Stages of Liver Diseases with Different Etiology
Zora Vukobrat-Bijedic, Azra Husic-Selimovic, Lejla Mehinovic, Dzelaludin Junuzovic, Nina Bijedic, Amela Sofic, Ivana Bjelogrlic, Amila Mehmedovic.
Background: Various complications occur in patients with advanced stages of liver diseases. Renal dysfunction, a parameter included in the meld score, is the most important prognostic factor. There is a strong need in clinical practice to estimate the gfr in this patients. Objectives: The aim of our study was to detect differences in renal function among patients with different stages of chronic liver diseases caused by hbv and hcv, also to determine the impact of viral etiology and gender on the values of egfr and renal function. Patients and Methods: This was an observational cross-sectional study performed on patients with hbv and hcv chronic hepatitis, cirrhosis and hcc caused by these viruses hospitalized during period 20092014 in the Clinic of Gastroenterohepatology, Clinical Center University of Sarajevo. The estimated gfr (egfr) was evaluated by the mdrd4 method. For the processing of data spss 21.0 statistical software was used. Statistical methods used in this study where: analysis of variance test (anova test), Students t-test for independent samples and Pearson coefficient of correlation. The level of significance was p
Key words: renal and hepatic injury, renal insufficiency, egfr.