In this study effect of gamma irradiation sterilization and storage conditions on thermal properties of phase sensitive granisetron in situ forming implant (ISFI) was investigated. ISFI was prepared by mixing Poly(DL-lactide-co-glycolide) (PLGA) with dimethylsulfoxide (DMSO):propylene carbonate (PC) (1:1) solvent combination then granisetron HCl was added and homogenized. Following application of gamma irradiation, ISFI was stored at 25oC for 4 months. Differential Scanning Calorimeter (DSC) and Thermogravimetric Analysis-Differential Thermal Analysis (TGA-DTA) analysis were carried out on fresh, irradiated and aged forms of granisetron ISFI. According to DSC and TGA-DTA thermograms and mass loss results application of gamma irradiation and storage of irradiated ISFI at 25oC for 4 months have not significant effect on thermal stability of ISFI.
Key words: In situ forming implant, Poly(DL-lactide-co-glycolide), Gamma irradiation sterilization, DSC, TGA-DTA, Stability
|
