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Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients

Sudha Jha, Shailaza Shrestha, Hundal Parchwani, Rahul Rai.

Abstract
Background: Hypertension is a hallmark risk factor for coronary heart disease, cerebrovascular stroke, congestive heart failure, cardiac arrhythmia, cardiomyopahy and abnormal renal function. Free radicals are involved in the pathogenesis of hypertension by altering endothelial function via oxidative stress.

Aims & Objective: To assess the level of antioxidant enzymes superoxide dismutase (SOD), Catalase, Glutathione peroxidase (GPX) and lipid peroxidation product malondialdehyde (MDA) in hypertensive patients.

Materials and Methods: 100 hypertensive patients and 25 healthy controls were included. Serum levels of enzymes and MDA were estimated by spectrophotometric methods.

Results: The level of antioxidant enzymes were significantly lower and MDA was significantly higher in hypertensive patients as compared to controls (p0.05). We also compared the enzymes and MDA level within the hypertensive groups. Significant results were obtained (p

Key words: Oxidative stress, Malondialdehyde(MDA), glutathione peroxidase(GPX), Superoxide dismutase(SOD), Catalase


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