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Review Article

J Pak Med Assoc. 2014; 64(6): 686-689


Foetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia — a systemic review and meta-analysis of randomized controlled trials

Wei Shan, Yang Wu, Guizhen Huang, Li Zeng,Miao, Yuan, Lugang Huang, Bo Xiang, Xiaoping Jiang.


Abstract

To evaluate and analyze the effect of foetal endocsopic
tracheal occlusion (FETO) therapy on survival rates of
neonatal with congenital diaphragmatic hernia and
maternal complications.
We performed a systemic review and meta-analysis of
three randomized controlled trials (RCTs). The combined
data on neonatal survival rates, length of gestational age
and rates of premature rupture of membrane from these
studies were retrieved and analysed.
Pooled data of these three RCTs revealed that FETO
provided neonates with severe congenital diaphragmatic
hernia a significantly higher survival rate: 27/48 VS 12/52.
The odds ratio was 5.95 (95% CI: 2.11 - 16.79, p

Key words: Foetal endocsopic tracheal occlusion, Congenital diaphragmatic hernia, Survival, Maternal complications.






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