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RMJ. 2014; 39(4): 376-380

Bone mineral density (BMD) and biochemical markers in evaluation of bone health in women

Uma Gupta, Shruti Sharma, Narendra Kumar Gupta.


Objectives: To determine the incidence of osteopenia and osteoporosis in women aged between 40-65 years and find the association between BMD and biochemical parameters.
Methods: The present study was conducted in women aged between 40-65 years visiting Gynaecology Outpatient Department. Body mass index (BMI) was calculated, BMD values were measured in terms of T-scores and Z-scores. Estimation of serum biochemical and serum FSH level was done.
The statistical analysis was done using SPSS (Statistical Package for Social Sciences) Version 15.0.
Result: Low BMD was observed in 35% out of which 30% had oesteopenia and 5% were having osteoporosis. 88.6% of subjects having BMI between 18 to 25 kg/m2 had low BMD, whereas only 11.4% having BMI between 24-30 kg/m2 were found to be suffering from low bone mass. Low serum calcium levels were seen in 54.3% women having low BMD. Higher levels of serum alkaline phosphatase and serum FSH seemed to be associated with low BMD.
Conclusions: We found that 65.7% of subjects between 40-50 years and 22.9% of cases between 51 to 60 years had low BMD. In women having serum calcium level less than 8.7 mg% chance of having osteopenia and osteoprosis was almost similar in both perimenopausal and post menopausal women. Higher FSH levels were found to be associated with bone loss.

Key words: Osteoporosis, bone mineral density, biochemical markers

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