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Understanding gender differences in the clinical presentation of Chronic Obstructive Pulmonary Disease: a cross-sectional study.

Lalita Fernandes, Anthony Menezes Mesquita.




Abstract

Background: COPD is projected to be the third leading cause of death by 2030. Tobacco smoke is the biggest risk factor for COPD in developed countries. In a developing country like India, the prevalence of smoking is low in women (3.6% in women and 26.25% in men), however the prevalence of COPD is equal in men and women (2-22% in men and 1.2- 19% in women). The biggest risk factor for COPD in women is exposure to biomass smoke but the awareness of COPD in non smoking women is low among treating physicians and hence women with COPD symptoms are diagnosed late leading to increased mortality and morbidity. We planned to evaluate any differences in clinical presentations so that these differences can help in early detection of COPD in women.

Methods: - Cross sectional study in a respiratory disease hospital outpatient clinic. Sampling method was a continuous convenience sampling. We included 200 stable COPD patients both men and women. Data was collected on clinical characteristics of cough, wheeze and breathlessness, lung function parameters of FEV1, FVC and FEV1/FVC, BMI and exercise capacity as assessed by six-minute walk distance. These parameters were then compared in men and women.

Results: 57.5% were men and 42.5% were women. 99% of the men with COPD were smokers, while 2.4% of the women were smokers only (P=0.001). 0.86% of men reported exposure to biomass smoke while 58.8% of women were exposed to biomass smoke (P=0.001). Both presented with cough, sputum, dyspnea, similar lung functions and BMI. Women reported significant dyspnea (P=0.04) and had lower exercise capacity as compared to men (P=0.001).

Conclusions: Women with COPD reported higher exposure to biomass smoke and had similar clinical presentations of COPD as men except for dyspnea and exercise capacity.

Key words: Biomass smoke exposure COPD (Chronic Obstructive Pulmonary Disease) Hour- Years Indoor Air Pollution Smoking.






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