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Original Article

J App Pharm Sci. 2014; 4(5): 021-024


STUDIES ON THE PRODIGIOSIN PRODUCTION FROM STREPTOMYCES COELICOLOR IN LIQUID MEDIA BY USING HEATED LACTOBACILLUS RHAMNOSUS

Do NA Huy, Nguyen HK Nguyen.

Abstract
Prodigiosin (PG) is not only an antibiotic but it has also been characterized immunosuppressive and anticancer activities. Prodigiosin is produced by Streptomyces coelicolor and Seratia marcescens. In this study, prodigiosin (PG) production of S. coelicolor was optimized using 50l, 100l heated cells at 70oC and 100oC of Lactobacillus rhamnosus. With 50l heat-killed cells at 70oC L. rhamnosus, Prodigiosin (PG) production of S. coelicolor enhanced the maximum prodigiosin concentration (9.79 1.68 mg/l) by six-fold at the early stage in the second day incubation in the comparison with prodigiosin (PG) production of S. coelicolor without heated L. rhamnosus (1.43 0.22 mg/l). There were the affects of the components of L. rhamnosus on PG production. This is the first report that L. rhamnosus affecting on PG production in S. coelicolor.

Key words: Lactobacillus rhamnosus, prodigiosin, Streptomyces coelicolor, temperature



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