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Comparative efficacy of Diazepam, Ketamine, and Diazepam-Ketamine combination for sedation or anesthesia in cockerel chickens

Muhammad Abdullahi Mahmud, Peter Shaba, Helen Yarubi Yisa, James Gana,Usman Yahaya Zubairu, Ruth Ndagimba, Silas Ndagi.

The comparative efficacy of Diazepam, Ketamine, and Ketamine-Diazepam combination was assessed using adult chickens (n=30). The chickens were divided into three equal groups (G-1, G-2 and G-3), and were administered with Diazepam dosed at 0.5 mg/kg body weight (b.wt.), Ketamine HCL dosed at 20 mg/kg b.wt., and Ketamine HCL (dosed at 10 mg/kg b.wt.) combined with Diazepam (dosed at 2 mg/kg b.wt.) through intramuscular (IM) route. The means of induction period, duration of sedation or anesthesia, full recovery period and duration of analgesia were significantly (p≤0.05) differed from one another. Similarly, the clinical and hematological parameters measured before and after the sedation or anesthesia within the groups were found to be differed significantly (p≤0.05) from each other. It was concluded that Diazepam dosed at 0.5 mg/kg b.wt. (IM) can be used in cockerels. However, combination of Ketamine (at 10 mg/kg IM)-Diazepam (at 2 mg/kg b.wt. IM) is preferably recommended as this combination is comparatively safer, and minimizes the pains elicited from the procedure of using Diazepam alone.

Key words: Anesthesia, Cockerel chicken, Diazepam, Ketamine, Ketamine-Diazepam combination, Sedative

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American Journal of Physiology, Biochemistry and Pharmacology


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