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Original Research

Histopathological study of vesiculobullous lesions of the skin; A study at tertiary care hospital

Prashant R Patel, Priti B Patel, SG Chiplonkar.


Background: Vesicles and bullae are fluid filled cavities formed within or beneath the epidermis. They may occur in many dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic conditions. Diagnosis of vesiculobullous diseases are often challenging on histopathology examination through clinical examination often required for correct diagnosis of it.

Aims & Objective: To study histopathological changes by light microscopy in vesiculobullous disorder of the skin and to correlate clinical and histopathological aspects of vesiculobullous disorder of the skin.

Materials and Methods: Histopathological study of vesiculobullous lesions of skin of 33 cases was carried out on skin biopsies were sent in 10% formalin to histopathology section. It was kept for 24 hours in 10% formalin for proper fixation, subsequently dehydration, clearing, embedding in paraffin wax were carried out. Blocks were made, sections of 3μm thickness were cut and stained with Harris Haematoxylin and Eosin stain and observed microscopically.

Results: In the present study 33 cases of vesiculo-bullous lesions of the skin were diagnosed histopathologically. Pemphigus group of diseases comprises the single largest group of 22 cases (66.66%) observed. the maximum numbers of subjects (51.55%) were in 3rd and 4th decades.

Conclusion: Punch biopsy is a simple, inexpensive, safe OPD procedure, causing minimal discomfort to the patient and no scarring. Clinical examination along with histopathological examination of skin both together help to arrive at correct diagnosis of diseases.

Key words: Histopathological Study; Skin Biopsies; Vesiculobullous Lesions

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