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Case Report

J App Pharm Sci. 2014; 4(8): 075-076

Three cases of Iohexol induced seizures in paediatric patients undergoing CECT head and the role of pharmacovigilance

Vyas Rathaur, Hemant Kumar Dutt, Varun Rawat, Pankaj Joshi.

In the modern era, the highly specific radiological investigation are on an increase and most of them mandates the use of contrast agents. These contrast agents are not free of adverse reactions and some of them are even potentially life threatening. Strictly implementing Knowledge, Awareness and Practice (KAP) in the institution. Contributing knowledge to the medical literature about the incidence of Iohexol induced seizure, which might be on an increase on the global level. Awareness by means of Pharmacovigilance Programme (PvP) to ensure the safety of the patient. Within the short period of three days, three cases of contrast induced seizures were reported by the Department of Paediatric and were treated accordingly. The Department of Pharmacology, expedited all the three cases to the National Co-ordinating Centre, Ghaziabad, India by entering the data into Vigiflow and also directed the chief pharmacist of the drug store to immediately stop the use of Iohexol with same batch number to prevent further risk .The importance of implementing the pharmacovigilance is the patientís safety which should be the utmost priority and we should be prompt enough to execute our responsibility for the benefit of the mankind.

Key words: ADR, Iohexol, KAP, Seizure, PvP

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