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Original Article

BTDMJB. 2015; 11(1): 17-23

To investigate possible etiologic factors of organic and functional dyspepsia in Turkey

Senem Karabulut, Mehmet Karabulut, Cevher Akarsu, Mehmet Abdussamet Bozkurt, Süleyman Bademler, Ali Kocataş, Sema Basat, Halil Alış.

Objective: Dyspepsia can be defined as a combination of unspecific symptoms with gastrointestinal origin and patients with dyspepsia reveal pathologies associated with dyspepsia called organic dyspepsia; if no local or systemic disease can be found as the cause called functional dyspepsia. In this article we aimed to investigate possible etiologic factors and prevalance of organic and functional dyspepsia in Turkey.
Material and Methods: This prospective study included the first 200 adult patients regardless of gender who presented with complaints of dyspepsia and 100 patients of control group since June 2008. All of them underwent hemogram, biochemical analysis, fecal testing, upper gastrointestinal endoscopy, abdominal ultrasound, and those with ulcer, gastritis and pathology in their gallbladder were considered to have organic dyspepsia.
Results: The study included a total of 200 patients of which had dyspepsia. Upper gastrointestinal endoscopy showed gastritis or ulcer in 71 (35.5%) patients, 33 patients (16.5%) with pathology gallbladder detected on abdominal ultrasonography. There were 12 patients (6%) with both stomach and gallbladder pathologies, thus the number of patients in organic dyspepsia group was 92. The remaining 108 patients without any finding neither on ultrasonography nor on upper gastrointestinal endoscopy comprised functional dyspepsia group.
Conclusions: In our study, an organic cause could be established in 46% of the patients with dyspepsia. The most important causes of organic dyspepsia are upper gastrointestinal pathologies (77% of organic dyspepsia). Biochemical studies performed on patients with dyspepsia in our study showed no difference compared to control group in terms of any parameters including serum amylase and lipase.

Key words: Functional dyspepsia, organic dyspepsia, pancreatic disorders, lipase

Article Language: Turkish English

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