| Case Report | 
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Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
Gentian Kaloshi, Arben Roji, Arsen Seferi, Bujar Cakani, Teona Bushati, Ermir Roci, Mentor Petrela. Abstract |  Download PDF | |  Post | Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear. To date, no causal responsibility of Bevacizumab (BEV) was noted. Here, we report for the first time, a case of thoracic intramedullary metastases from a cerebral glioblastoma pre-treated with BEV. A critical and exhaustive review is provided.
Key words: Glioblastoma, lepto-meningeal seeding, bevacizumab.
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