Home|Journals|Articles by Year|Audio Abstracts

Case Report

Open Vet J. 2023; 13(12): 1760-1768

Extreme lymphocytosis in a dog with T-zone lymphoma

Bruna Voltolin de Sena, Bárbara Correa de Mello, Rodrigo dos Santos Horta, Mariana de Pádua Costa, Marilia Martins Melo, Reysla Maria da Silveira Mariano, Rodolfo Cordeiro Giunchetti, Antonio Giuliano, Fabiola de Oliveira Paes Leme, Adriano de Paula Sabino, Paulo Ricardo de Oliveira Paes.

Cited by 0 Articles

Canine T-zone lymphoma is recognized as an indolent CD45- T cell lymphoma, with low aggressiveness and high overall survival. The diagnosis is obtained by histopathology and immunohistochemistry, but also by cytological examination of the lymph node associated with immunophenotyping. Lymphocytosis is commonly identified as around 10,000 cells/µL and may reach 30,760 cells/µL.
Case Description:
The present report describes a case of a female Golden Retriever, nine years old, with generalized lymphadenopathy. In the cytological examination of the superficial cervical lymph node a monomorphic population of small, “clear cells” “hand mirror” lymphocyte shape was suggestive of T-zone lymphoma. The leukogram showed intense leukocytosis (160,050 cells/μL) due to small clear cell lymphocytosis (152,048 cells/μL). The myelogram showed a myeloid:erythroid ratio of 2.3; with a pyramidal distribution of cell types and the presence of 22.8% of lymphocytes in the differential count. Bone marrow, peripheral blood and lymph node immunophenotyping resulted in lymphocyte gates with 97.3 to 99.5% CD5+, predominantly CD4-, CD8- and CD45- confirming the diagnosis of T-zone lymphoma with associated leukaemia. Treatment with chlorambucil and prednisolone was started. During the first month, the lymphocytosis remained above 200,000 cells/uL. After four months of treatment, there was a decrease in lymphocytes, which progressively reached a count of 10,800 cells/ul in the eleventh month.
In the literature, lymphocytosis above 30,760 cells/μL has not been observed in T-zone lymphomas. Thus, it is believed that this is the first report of extreme lymphocytosis with an unusually slow response to treatment in this neoplasm.

Key words: Cytology, Flow cytometry, Immunophenotyping, Indolent lymphoma, Lymphocytosis

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.