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C-glycosyl flavonoids-rich extract of Dipcadi erythraeum Webb & Berthel. bulbs: Phytochemical and anticancer evaluations

Mona M. Marzouk, Ahmed Elkhateeb, Rasha R. Abdel Latif, El-Sayed S. Abdel-Hameed, Salwa A. Kawashty, Sameh R. Hussein.

Abstract
Dipcadi erythraeum Webb & Berthel. is a wild edible species belonging to family Asparagaceae and commonly used in the folk medicine. The Dipcadi erythraeum bulbs extract was subjected to chemical investigation using LC-ESI-MS technique to identify its polar active constituents and evaluated against four human carcinoma cell lines; MCF7, HEPG2, A549 and HCT116. The D. erythraeum bulbs extract revealed 22 phenolic compounds characterized for the first time from the studied species, 14 of them were identified as C-glycosyl flavonoids. Moreover, the studied extract showed a moderate activity against MCF7 and HCT116 at 100 g/mL with cell viability 43.6% and 48.4%, respectively. From the chemotaxonomic point of view, the presence of C-glycosyl flavonoids supported that D. erythraeum has a closer relationship with the species of Asparagaceae family than Liliaceae.

Key words: Dipcadi erythraeum, C-glycosyl flavonoids, LC-ESI-MS, Cytotoxic activity



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