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Effect of gabapentin on pressor response to laryngoscopy and tracheal intubation in patients undergoing elective cholecystectomy

Emeema Bandrapalli, Ramesh Kalapala, Neeraja Malapolu, Arun Krishnan, Hima Bindu Gujjarlamudi.


Background: Laryngoscopy and tracheal intubation trigger sympathetic activity, increasing heart rate (HR) and blood pressure. Various approaches have been tried to reduce the pressor response.

Aims and Objectives: The main objective of this study was to assess the effect of gabapentin on pressor response in patients undergoing elective cholecystectomy.

Materials and Methods: Patients with ASA grades 1 and 2 who were diagnosed with uncomplicated gall bladder stones on ultrasound in the age group of 18–60 years were randomly allocated into two groups. Group G received gabapentin 600mg orally, and group P received a matching placebo orally 2 h before surgery. Anesthesia was induced by propofol (2 mg/kg) and fentanyl (3 μg/kg). Intubation was facilitated with vecuronium bromide (800 μg/kg). The patient’s HR, systolic blood pressure, diastolic blood pressure, and mean blood pressure were monitored just before (0 min) and after 1, 3, 5, and 10 min of endotracheal intubation.

Results: The demographic data of patients were similar in both groups. The mean age was 46.95 ± 6.50 and 49.20 ± 6.38 in the gabapentin group and placebo group, respectively. When compared to the placebo group, the gabapentin group showed significantly lower systolic, diastolic, and mean arterial pressure at 1, 3, 5, and 10 min after intubation.

Conclusion: Gabapentin reduced systolic, diastolic, and mean arterial pressure after intubation in patients undergoing elective cholecystectomy.

Key words: Pressor Response; Endotracheal Intubation; Gabapentin

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