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Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens

Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere.


The antimicrobial activities of aqueous (cold and hot) and ethanolic extracts of leaf stem bark and root of Cyathula prostrata were investigated against some human clinical isolates of Staphylococcus aureus, Streptococcus mutans, Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, and Candida albicans using the Agar well diffusion method at extract concentration of 25mg/ml. Ciprofloxacin(5μg/ml) and Fluconazole (20μg/ml) drugs was used as positive reference standards to determine the sensitivity of the strains. Results obtained showed that all the test isolates were inhibited by various fractions of the leaf, root and stem bark extracts. The antimicrobial activities of the different plant parts were not significantly different (P

Key words: Cyathula prostrata, aqueous extract, ethanol extract, antimicrobial activity

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