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Increased of Langerhans Cells in Smokeless Tobacco-Associated Oral Mucosal Lesions

Érica Dorigatti de Ávila, Rafael Scaf de Molon, Melaine de Almeida Lawall, Renata Bianco Consolaro, Alberto Consolaro.

Abstract
Objective: To evaluate the changes in the number of Langerhans Cells (LC) observed in the epithelium of smokeless tobacco (SLT-induced) lesions.
Methods: Microscopic sections from biopsies carried out in the buccal mucosa of twenty patients, who were chronic users of smokeless tobacco (SLT), were utilized. For the control group, twenty non-SLT users of SLT with normal mucosa were selected. The sections were studied with routine coloring and were immunostained for S-100, CD1a, Ki-67 and p63. These data were statistically analyzed by the Student’s t-test to investigate the differences in the expression of immune markers in normal mucosa and in SLT-induced leukoplakia lesions.
Results: There was a significant difference in the immunolabeling of all markers between normal mucosa and SLT-induced lesions (p

Key words: Smokeless tobacco, leukoplakic lesions, cancer, langerhans cells, chewing tobacco.


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