Flacourtia jangomas (Lour.) Raeusch is a fruit plant that belongs to the Salicaceae family and is generally known as the Indian plum. F. jangomas has been explored for the curing of various diseases. The present study intended to evaluate the safety profiling of F. jangomas fruit (FJF) and leaf (FJL) methanolic extract at a single-dose oral administration of 50 mg/kg body weight (b.wt), 300 mg/kg b.wt, and 2000 mg/kg b.wt in Sprague Dawley rats. Behavioural patterns, signs, body weight, water, and feed consumption of rats were observed throughout the 14-day study period. At the end of the study, the parameters such as hematological and biochemical were evaluated. Further, the architecture and histology of the organs (heart, kidney, liver, and lung) were also observed. The study revealed that the methanolic extract of FJF and FJL did not cause any mortality up to 2000 mg/kg b.wt. No significant variations were found in the haematological and biochemical parameters of all treated groups when compared to the control group. In addition, histological changes were not detected in the heart, kidney, liver, and lung of the treated groups. Overall, there were neither any toxicity signs nor deaths were noticed during the study period. The oral administration of methanolic extract of FJF and FJL did not have any toxic effect in rats. Hence, it could be considered safe to use for further exploring the medicinal value of this plant.
Key words: Flacourtia jangomas, Sprague Dawley rats, Histology, Toxicity
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