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Original Research

RMJ. 2014; 39(3): 337-340

Effect of chronic restraint stress on hypothalamo pituitary adrenal axis response and body weight of male and female Sprague Dawley rats

Sadaf Hasan, Sadaf Jafar, Abrar Hussain Azad, Sadia Haroon, Misbah Hasan.

Objective: To study the effects of chronic restraint stress on body weight with respect to serum corticosterone levels in Sprague Dawley rats.
Methodology: This experimental study was carried out at Department of Physiology, Army Medical College, Rawalpindi & NIH Islamabad, Pakistan from January 2008 to December 2008. Out of a total of 150 rats, 90 were female and 60 were male.They were divided into five groups; Group I and II were control groups where as III, IVa, IVb were experimental groups. The control male rats were exposed to chronic restraint stress where as the experimental female rats were exposed to the similar stress regimen. Later they had removal of both ovaries. Half of the ovariectomized rats (n=30) were given once daily injection of 17- β estradiol for two weeks. The body weights of the male and female Sprague Dawley rats were recorded both at the start and end of study.
Results: The stress resulted in an increase in serum corticosterone levels in experimental male rats (21.663.67 ng/ml, p

Key words: Hypothalamo pituitary adrenal(HPA) axis, Stress, Corticosterone, Restraint, Body weight, Ovariectomy, Estradiol

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