Background:
Many of flavonoid rich natural products found to have a significant influence on postprandial hyperglycemia, a major risk factor for diabetic complications. Enhancement of insulinotropic gut hormones by inhibition of Dipeptidyl peptidase-IV (DPP-IV) are among the newest strategies for treatments of type 2 diabetes .
Aim: This study was designed to investigate the potential role of standardized grape seed proanthocyanidin (GSP) in controlling postprandial hyperglycemia by enhancing the regulatory incretin effect of gut hormones in response to oral and intraperitoneal glucose load in healthy rats .
Method:
Five groups of animals each of six rats were used in this study which was conducted in march 2013. groups (I and IV) treated with single oral dose of proanthocyanidin (50mg/Kg) , groupII received single oral dose of sitagliptin (40mg/Kg) and groups (III and V) treated with vehicle. All treatments were given thirty minutes before oral or intraperitoneal glucose load. Blood glucose was estimated over two hours duration at(0,30,60,90 and 120)minutes from glucose load.
Result: Both proanthocyanidin and sitagliptin significanthly improve hyperglycemia induced by oral glucose load relative to control. While non significant changes was achieved by proanthocyanidin after intraperitoneal glucose challenge compared to untreated control group.
Conclusion: The result of this study indicated that proanthocyanidin may possess an enhancement of incretin effect of gut peptides which could be responsible for some of its action on glucose homeostasis. This finding may provide opportunity for further pharmacological studies using more specific models to clarify the possible action of proanthocyanidin as a natural DPP-IV inhibitor.
Key words: proanthocyanidin, postprandial hyperglycemia, Sitagliptin .
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