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Original Article

J App Pharm Sci. 2014; 4(7): 041-046

Invitro study on the efficacy of Zinc Oxide and Titanium Dioxide nanoparticles against Metallo beta-lactamase and Biofilm producing Pseudomonas aeruginosa

Mary Grace Vincent, Neetu Peedikayil John, Narayanan PM, Vani C and Sevanan Murugan.


Background: Pseudomonas aeruginosa contributes to a multitude of infections exhibiting intrinsic resistance to numerous antibiotics. Metallo beta-lactamase and biofilm production is the most worrisome resistant mechanisms observed in P. aeruginosa. Emergence of antimicrobial resistance by pathogenic bacteria is a major health problem in recent years. Zinc oxide and titanium dioxide nanoparticles comprises of well-known inhibitory and bactericidal effects. Objectives: The present study is designed to determine the efficacy of zinc oxide and titanium dioxide nanoparticles against metallo beta-lactamase and biofilm producing P. aeruginosa. Methodology: A total of 51 non-repetitive P. aeruginosa isolates were obtained from Bioline laboratory, Coimbatore. Biofilm and metallo beta-lactamase production was tested by combined disc test and tissue culture plate method. Commercially available zinc and titanium dioxide nanoparticles were obtained and tested against two metallo beta-lactamase and biofilm producing isolates. Results: Both the nanoparticles showed appreciable activity at all tested concentrations. Conclusion: Thus, it is concluded that ZnO and TiO2 nanoparticles may serve as a promising antibacterial agents in coming years.

Key words: Pseudomonas aeruginosa, Biofilms, Metallo beta-lactamase, Zinc oxide nanoparticles, Titanium dioxide nanoparticles, Antibiotic resistance

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