Introduction: Idiopathic recurrent oral aphthosis or recurrent aphthous stomatitis (RAS) is a benign disease of the oral cavity that affects a significant portion of the population. Despite numerous studies, its aetiology often remains unknown and there is no ideal therapeutic approach. The differential diagnosis is vast.
Case Report: We present a 16-year-old female with complaints of multiple oral thrushes within two months of evolution, unresponsive to usual topical treatments. She presented macrocytosis (maximum VGM 133 fL), vitamin B12 levels within reference values and folic acid levels at the limit of normality. With other negative investigations, having opted for vitamin B12 supplementation with complete resolution of her complaints.
Our objective was to confirm the beneficial treatment of RAS with vitamin B12 supplementation.
Conclusion: Treatment with vitamin B12 is simple, inexpensive and low risk and seems to be effective for a large percentage of patients suffering from RAS, regardless of serum vitamin B12 level.
Key words: Cyanocobalamin, Macrocytosis, Pediatric age, Recurrent aphthous stomatitis, Vitamin B12
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