Abstract

Chemicals/ drugs-induced hepatotoxicity has become one of the major concerns in medical practice. This study was designed to evaluate the possible protective effects of diphenyl diselenide (DS) against carbon tetrachloride (CCl4) and diethylnitrosamine (DEN)-induced hepatotoxicity in male Wistar rats. Forty male Wistar rats (100-120 g) were assigned into five groups of eight animals. Group 1 served as control, group 2 was given DEN (100 mg/kg) + CCl4 (0.5 ml/kg), group 3 received DEN (100 mg/kg)+ CCl4 (0.5 ml/kg) + DS (5 mg/kg), group 4 received DEN (100 mg/kg)+CCl4 (0.5 ml/kg)+DS (10 mg/kg), and group 5 received DEN (100 mg/kg)+CCl4 (0.5 ml/kg)+Quercetin (QUE; 50 mg/kg). Administration of DEN and CCl4 increased the activities of serum alanine aminotransferase, myeloperoxidase and total bilirubin level relative to controls. There were significant (p

Key words: Diphenyldiselenide, Diethylnitrosamine, carbon tetrachloride, hepatotoxicity, oxidative stress