Background: Laryngoscopy and endotracheal intubation, pneumoperitoneum, and tracheal extubation may lead to adverse hemodynamic responses during laparoscopic surgeries under general anesthesia.
Aims and Objectives: The present study aimed to compare the effectiveness of oral pregabalin and oral clonidine on perioperative hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia.
Materials and Methods: Sixty patients aged 18–60 years of the American Society of Anesthesiologists Physical Status I or II were randomly divided into two groups. Group C (n = 30) received oral clonidine 200 μg and Group P (n = 30) received oral pregabalin 150 mg as a premedication undergoing laparoscopic cholecystectomy under general anesthesia. The hemodynamic variables, i.e., heart rate, systolic, diastolic, mean arterial blood pressure, along with the duration of post-operative analgesia, level of sedation, and any adverse effects were noted. The data to be analyzed were entered into Microsoft Excel and statistical analysis was done using the Statistical Package of the Social Sciences version 16 software.
Results: The attenuation of hemodynamic response following laryngoscopy and endotracheal intubation, pneumoperitoneum, and extubation was significantly better in clonidine group. Group P (655.8 ± 282.0 min) (P < 0.05) had significantly prolonged duration of post-operative analgesia as compared to Group C (295.8 ± 54.6 min) (P < 0.05). Group P showed significantly higher sedation scores before induction (P < 0.05). Mean total rescue analgesic consumption was significantly lower in Group P (P < 0.05). Side effect profile was comparable in two groups (P > 0.05).
Conclusion: Clonidine and pregabalin both were found to be effective in attenuation of perioperative hemodynamic response. However, pregabalin prolonged the duration of analgesia along with lesser rescue analgesic consumption, acceptable sedation, and no or minimal side effects.
Key words: Pregabalin; Clonidine; Laparoscopic Cholecystectomy; Hemodynamic Response; Post-operative Analgesia; Sedation
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