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Na+ channel blocker enhances metformin effects on neuroblastoma cell line

Ali Taghizadehghalehjoughi, Ahmet Hacimuftuoglu, Aysegul Yilmaz.


The aim of the current study is the evaluation of valproic acid and Metformin antitumor effect on neuroblastoma (SH-SY5Y) and answer the question, is valproic acid (VPA) increase Metformin (MET) antitumor effect on the SH-SY5Y cancer cell line or not. The SH-SY5Y cell line was grown in culture medium. A different dose of MET and VPA were applied to SH-SY5Y cancer cell lines for 24 hrs. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell viability, Annexin-V-FITC apoptosis, Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) tests were done 24 hours after drug administration. As a result of the tests, the combination of MET and VPA reduced cancer cell viability compared with the control group (p

Key words: Flowcytometry, metformin, neuroblastoma, valproic acid, TAC, TOS

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