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Original Article

AJVS. 2023; 77(2): 42-46

Ameliorative Effect of N-acetylcysteine against Florofenicol-induced Intestinal Injuries in Broilers

Ashraf Elkomy, Soad S. Belih, Faten Elsayed, Elrefaey Aboelftouh, Hawary S. Ibrahiem.


This study was designed to evaluate the Ameliorative effect of N-acetylcysteine (NAC) against possible florfenicol (FFC)-induced intestinal injuries in broiler chicks. A total of 120 broiler chicks were allocated into 4 equal groups. Group (1) was kept as a control, while group (2) administered with NAC (100 mg ̸ L of drinking water for 5 days from 15 to 20 days of age. Group (3) was administered with toxic dose of FFC (60mg ̸ kg B.Wt.) orally for 5 days from 18 to 22 days of age. Group (4) was co-administered with NAC with FFC with the same previous doses on the same treatment periods. The histopathological examination was performed to evaluate NAC-ameliorative effects. Results ensure that FFC induced intestinal injuries in broilers and NAC can ameliorate such deleterious effects which reflected by an enhancement histopathological findings.

Key words: Florfenicol, N-acetylcysteine, intestines and broiler chicks

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