Objectives: To investigate whether serum levels of inflammatory markers including high sensitive C-reactive protein (hs-CRP) and mean platelet volume (MPV) to platelet count ratio (MPR) were altered in patients with hyperemesis gravidarum (HEG) compared to asymptomatic pregnant women.
Methods: Ninety pregnant women, 46 with HEG and the other 44 with healthy uncomplicated pregnancies were included the study. MPR was calculated as the MPV value to the platelet count obtained from the same blood sample. The clinical information and the laboratory results of the hematologic and biochemical parameters and hs-CRP levels of each participant were recorded.
Results: Platelet counts were didnt differ between the groups. MPV, MPR and hs-CRP values were significantly higher in HEG group than in the control (p=0.01, p=0.05 and p=0.03, respectively).
Conclusions: The etiopathogenesis of HEG is still obscure and its likely multi-factorial. Although we didnt demonstrate the statistically significant differences in terms of platelet counts between the groups we find elevated levels of MPV, MPR and hs-CRP which conclude inflammatory basis of the disease.
Key words: C-reactive protein, hyperemesis gravidarum, inflammation, platelet,
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