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Modulation of glucose and lipid metabolism in adrenalectomised rats given glycyrrhizic acid

Yan Qi Ng, Chanchal Chandramouli, So Ha Ton, Khalid Abdul Kadir, Fahreen Haque, Melissa Sharmini Tamotharan.

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Background: Glycyrrhizic acid (GA) was found to improve blood glucose and dyslipidaemia with increased lipoprotein lipase (LPL) expression and reduction in 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), hexose-6-phosphate dehydrogenase (H6PDH), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) activities in liver, kidney, skeletal muscles and adipose tissues. However, it was not known if these were a direct action from GA or indirect involving glucocorticoids (GC).
Methods: Adrenalectomised (ADX) rats were used to investigate the effects of GA administration on glucose and lipid metabolism in the absence of endogenous GC. Thirty male Sparague Dawley rats were randomly assigned to three groups of ten; designated the sham, ADX and GA-administered (100mg/kg; orally) ADX groups. After 28 days of treatment, the blood samples collected were analysed for glucose, serum insulin and lipid profiles. Tissues collected were analysed for LPL expression and 11β-HSD1, H6PDH, PEPCK and G6Pase activities.
Result: Improvement in blood glucose level was seen in ADX compared to the sham rats (33%; p0.05). Adrenalectomy also led to significant reduction in PEPCK (p

Key words: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1); Adrenalectomy; Glycyrrhizic acid; Lipoprotein lipase (LPL); Metabolic syndrome

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