The present study was designed to assess the nootropic activity of Polyherbal formulation (PHF) using Radial arm maze on scopalamine induced amnesia in rats. Ayurvedic Polyherbal formulation (PHF) consists of plant ingredients of Brahmi (Bacopa monniera), Shatavari (Asparagus racemosus), Ashwagandha (Withania somnifera) and Vacha (Acorus calamus). This Ayurvedic polyherbal preparation can be extensively used in the treatment of loss of memory and memory enhancement both in children and adults. In the current investigation, the nootropic and anticholinesterase action of plant extract of PHF at doses (200 and 400 mg/kg, p.o.) was assessed using animal models. The PHF treated group showed a dosage dependent substantial decline in the radial arm maze when compared to the corresponding control group. For memory intoxication, sodium nitrite and scopolamine were utilised. Anxiolytic activity in the treatment group was shown by the considerable (p0.001) increase in social engagement time. Additionally, as compared to the control group, the treated group demonstrated a substantial (p0.001) decline in anticholinesterase activity. Therefore, an improvement in spatial reference and spatial working memory corresponds to a drop in radial arm performance and a rise in the proportion of memory retention of PHF against scopolamine-induced dementia. As a result, polyherbal preparation demonstrated to be a viable treatment for cognition disorders.
Key words: Radial arm maze, Anticholinesterase, Polyherbal formulation, Nootropic.
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