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Use of enterocin MSW5 in combination with antibiotics to increase the antimicrobial and antibiofilm efficacy against foodborne pathogens

Mansi Umeshbhai Shukla, Dhruv Valand, Shilpa Akshaya Gupte.


The development of resistance to conventional antibiotics by pathogens is one of the major global health issues. To solve this problem, antimicrobial combinatorial therapy can be one of the alternatives. In this work, we have used an antimicrobial peptide in combination with antibiotics against foodborne pathogens. An antimicrobial peptide (AMP) (Enterocin MSW5) was produced by Enterococcus faecalis MSW5. To determine in vitro antimicrobial combinatorial therapy, five different antibiotics (oxacillin, tetracycline, vancomycin, doxycycline, and linezolid) were selected. Their minimum inhibitory concentration (MIC) was examined against three different foodborne pathogens. The MIC of Enterocin MSW5 was determined to be 0.36, 0.36, and 0.72 mg/mL against Staphylococcus aureus, Salmonella ser. Typhimurium, and Listeria monocytogenes, respectively. Further, the synergistic effect of antibiotics with Enterocin MSW5 was determined using a checkerboard assay. The fraction inhibitory concentration index (FICI) values were

Key words: Antibiotics, Biofilm, Enterocin MSW5, Checkerboard assay, Fractional Inhibitory Concentration Index (FICI), Synergistic effect

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