Home|Journals|Articles by Year|Audio Abstracts

Research Article

An In Vitro Evaluation of The Effect of Titanium Dioxide Nanoparticle on The Shear Bond Strength and Antimicrobial Property of Orthodontic Adhesive: A Systematic Review and Meta-Analysis

L Harsha, Aravind Kumar Subramanian*.


Objective: The objective of this review was to systematically analyse available literature on the effects of titanium dioxide
nanoparticles (TiO₂ NPs) in improving the antimicrobial activity and shear bond strength when incorporated in orthodontic
Methods: All invitro studies that have evaluated the shear bond strength and the antimicrobial activity of TiO2 NPs
infiltrated orthodontic adhesive were included in this review. A comprehensive search in 5 electronic databases namely,
Google scholar, PUBMED, EMBASE, Cochrane and Web of science were done up to January 2023. Using the reference
method for invitro studies, the Risk of bias ROB was evaluated. Meta-analysis using Random Effects Model was performed
for assessing the antimicrobial activity against S. mutans, C. albicans and L. Acidophilus.
Results: All the included studies had a moderate risk of bias. On qualitative analysis, a significant antimicrobial effect
against Streptococcus mutans and Lactobacillus acidophilus and a non-significant shear bond strength of TiO2 infiltrated
orthodontic adhesive was reported. The meta-analysis revealed a significant overall antimicrobial effect and non-significant shear bond strength values with a high heterogeneity.
Conclusion: An overall significant antimicrobial effect of TiO₂ infiltrated orthodontic adhesive against S. mutans and L.
Acidophilus was noted but with a high heterogeneity and a moderate risk of bias. An overall non-significant shear bond
strength of TiO₂ infiltrated orthodontic adhesive was noted but with a high heterogeneity and a moderate risk of bias.

Key words: Bacterial growth, smokers, non-smokers

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.