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Anticancer activity of Jasminum angustifolium Linn against Ehrlich ascites carcinoma cells bearing mice

Raju Asirvatham, Arulanandham Antonysamy, Pradeep Rajkumar, Lakshmi Narayanan.

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Objective: Present investigations were carried out for evaluation of antitumor and in vitro antioxidant activity of ethanol and aqueous extracts of Jasminum angustifolium Linn.
Methods: For its antitumor activity, Ehrlich ascites carcinoma (EAC) induced swiss albino mice were used and were divided into five group with 6 animal each.The antitumor effect was assessed using viable tumour cell count, packed cell volume, body weight, mean survival time and percentage increase in life span. Apart from that, hematological and liver enzyme studies were noticed upon the ethanol and aqueous extracts of Jasminum angustifolium Linn administered at 500 mg/kg per day for 14 days, after 24 hours of tumor inoculation.
Results: Treatment with extracts significantly restored the altered parameters to normal when compared to cancer control group.
Conclusion: The results suggest that ethanol extract of Jasminum angustifolium Linn possess significant antitumor effects in EAC tumour bearing mice.

Key words: Anticancer; Ehrlich ascites carcinoma; Jasminum angustifolium Linn; Mice

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