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Comparison of the Effect of Intramuscular Promethazine and Ondansetron in the Treatment of Peripheral Vertigo in Patients Presenting to the Emergency Ward

MOHAMADALI JAFARI, NASER MOHAMAD KARIMI, ALI RAEE, HAMID MIRJALILI, FAEZE ZEINALI.N, MOHAMMAD REZA RAFIEE DEHNAVI.


Abstract

Background & Objectives: Vertigo is often recognized as a gruesome clinical symptom in the emergency ward. Physicians often encounter problems with this complication in both the diagnosis and treatment phase. Vertigo is one of the most common causes for patient attendance at the emergency ward. Drug therapy is the most appropriate treatment for acute peripheral vertigo. Promethazine is one of the medicines used to treat acute vertigo in the emergency ward. This study evaluated the effect and complications of muscular promethazine and ondansetron in the treatment of peripheral vertigo.
Materials & Methods: This study was performed as a double-blind randomized clinical trial in teaching hospitals of Yazd. In so doing, 160 patients observing inclusion criteria were selected for the study and randomly assigned into promethazine and ondansetron groups. Then, 25 mg of intramuscular promethazine was administered to the promethazine group and 4 mg of intramuscular ondansetron was administered to the ondansetron group. Next, the severity of complications and clinical symptoms and the severity of vertigo at the time before and after receiving the drug for up to 2 hours were assessed.
Results: The results of the present study showed that there was no significant difference between the two groups in terms of age, sex, underlying diseases, duration of vertigo and clinical symptoms of patients (P

Key words: Acute peripheral vertigo, emergency, promethazine, ondansetron.






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