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Research Article

JCDR. 2021; 12(6): 1012-1016


Comparison of efficacy of different class of anti-hypertensive drugs prescribed in patients with hypertension

Dr. Laxman Kumar,Dr. Pankaj Kumar, Dr. Awadhesh Kumar Jha.


Abstract

Background:Hypertension is epidemic affecting one billion people and common risk factor
of death throughout the world. The present study compared efficacy of different class of antihypertensive
drugs prescribed in patients with hypertension.
Materials & Methods:84 cases of hypertension of both genders were divided into5 groups on
different drugs used for treatment. Group I had calcium channel blockers, group II had beta
blockers, group II had ACE inhibitors, group IV had angiotensive receptor blocker and group
V had diuretics. Parameters such as risk factors of hypertension, associated comorbidities,
assessment of blood pressure at baseline, after 15 days and 1 month was done.
Results: Out of 84 patients, males were 54 and females were 30. Common risk factors were
obesity in 24%, hyperlipidaemia in 26%, family history in 14%, smoking in 54% and
menopause in 24%. The difference was significant (P< 0.05). Associated co-morbidities were
diabetes mellitus in 52, COPD in 14, CAD in 40, hyperthyroidism in 11 and asthma in 5
cases. The difference was significant (P< 0.05). There was significant difference in systolic
and diastolic blood pressure recorded at baseline, after 15 days and 1 month in group II and
IV (P< 0.05).
Conclusion: Maximum efficacy was seen with calcium channel blocker and common risk
factors were obesity, hyperlipidaemia, family history, smoking and menopause

Key words: Hyperlipidaemia, hypertension, smokin






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