Cyclophosphamide is an alkylating agent that has been used for the treatment of severe manifestations of autoimmune inflammatory disease. Cyclophosphamide is widely used for the treatment of malignancies; it exerts its impact through the cessation of cell division. Cyclophosphamide is similar to other chemotherapies and has various toxicities; however, its toxicity is not well reported. This review was conducted to find out cyclophosphamide-related toxicities as reported in the previous studies conducted on that subject. A total of 91 articles were obtained, but only six studies were eligible for the inclusion criteria. The studies included a total number of 3,531 participants. Cyclophosphamide was associated with various toxicities, including liver toxicity, urotoxicity, cardiac toxicity, hematological, and non-hematological toxicities. The toxicity of cyclophosphamide varied based on the regimen and combined medications, as well as some gene variants.
Key words: Cyclophosphamide, Toxicity, Predictors, Outcomes
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