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JCDR. 2021; 12(6): 971-979

Comparative Study of Fractional Flow Reserve Guided PCI Versus Quantitative coronary angiography Guided PCI, Six Months Outcome

Ahmed Yousuf Nammour MD, Hesham Khaled Rashid MD, Mohamed Ahmed Abdel-MaksoudHamouda MD, and Ahmed Diab Abdelazim Diab M Sc.


Background: Coronary artery disease (CAD) is a leading cause of death and morbidity around the world,
Aim: to compare six months' clinical outcome of FFR guided PCI versus QCA guided PCI regarding MACE (composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization).
Methods: The study included 100 patients who were referred to the National Heart Institute for elective coronary revascularization with or without adjunct FFR. Patients were divided into two groups; Group I: Fifty patients underwent QCA Guided PCI group. Group II: Fifty patients underwent FFR-guided PCI group.
Results: In the QCA group, the mean QCA (diameter stenosis) was 69.12±3.99, while in the FFR group, the mean FFR was 0.7 ±0.04. No significant differences were noted between both groups regarding perforation, no-reflow, dissection, arrhythmia, or failed PCI (P = 1.0 for each). Regarding in-hospital related complications; No significant differences were observed between both groups regarding AKI (P = 1.0), bleeding (P = 1.0), shock (P = 1.0), mechanical ventilator (P = 1.0), or new ischemic event (P = 0.617). No significant differences were reported between both groups regarding MACE at 3 months (P = 1.0) and 6 months (P = 0.436).
Conclusion: FFR guided PCI was found to be non-inferior to QCA as regards the incidence of death, myocardial infarction, stroke, or repeat revascularization at 3 and 6 months in patients with stable coronary artery disease with intermediate stenosis.

Key words: Fractional Flow; PCI; coronary angiography

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