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Original Article

J App Pharm Sci. 2023; 13(11): 170-177


Synthesis, Mycobacterium tuberculosis H37Rv inhibitory activity, and molecular docking study of pyrazinamide analogs

Muhammad Zulqurnain, Nur Pasca Aijijiyah, First A. Wati, Arif Fadlan, Azminah Azminah, Mardi Santoso.



Abstract
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Pyrazinamide analogs 5a–h have been successfully synthesized by the Yamaguchi esterification method with yields ranging from 6% to 86%. Among pyrazinamides 5a–h, pyrazinamides 5d,g showed the best antituberculosis activity with MIC values

Key words: Pyrazine-2-carboxamides, Yamaguchi reaction, 2,4,6-trichlorobenzoyl chloride, antitubercular activity, molecular docking

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030405060708091011120102
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